BENDEX

Indications:

• Albendazole is used to treat neurocysticercosis, an infection of the nervous system caused by pork tapeworms
• Treat cystic hydatid disease of the liver, lung, and peritoneum, an infection caused by dog tapeworms.
• used to treat infections caused by worms. It works by keeping the worm from absorbing sugar (glucose), so that the worm loses energy and dies

Dosage:

• For hydatid disease of the liver, lung, and peritoneum:
  • Adults weighing 60 kilograms (kg) or more—Dose is based on body weight and must be determined by your doctor. The dose is usually 400 milligrams (mg) 2 times a day, taken with meals for 28 days (1 cycle). This is followed by not taking albendazole for 14 days, for a total of 3 cycles.
  • Adults weighing less than 60 kg—Dose is based on body weight and must be determined by your doctor. The dose is usually 15 mg per kg of body weight per day, divided into 2 doses, taken with meals for 28 days. This is followed by not taking albendazole for 14 days, for a total of 3 cycles. The dose is usually not more than 800 mg per day.
  • Children—Use and dose must be determined by your doctor.
• For neurocysticercosis:
  • Adults and children weighing 60 kilograms (kg) or more—Dose is based on body weight and must be determined by your doctor. The dose is usually 400 milligrams (mg) 2 times a day, taken with meals, for 8 to 30 days.
  • Adults and children weighing less than 60 kg—Dose is based on body weight and must be determined by your doctor. The dose is usually 15 mg per kg of body weight per day, divided into 2 doses, taken with meals, for 8 to 30 days.

Mechanism of action:

The principal mode of action for albendazole is by its inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules in the intestines of nematodes worms, ultimately causing energy depletion and death of the organism.