IMUTREX 2.5MG contains methotrexate which belong to a group of medicines called folate antagonist. It can be used to treat severe cases of psoriasis and rheumatoid arthritis. It can also be used to treat several kinds of cancer. Psoriasis is an autoimmune disorder that causes your skin cells to grow and multiply much quickly than normal cells. Methotrexate kills the rapidly multiplying cells in the skin. In rheumatoid arthritis, methotrexate reduce inflammation in joints by altering body’s defence mechanism in immune system. In cancer, methotrexate inhibits the enzymes responsible for nucleotide synthesis and prevents cell division.
Methotrexate is a folic acid antagonist; it tightly binds to dihydrofolate reductase and results in a deficiency in the cellular pools of thymidylate and purines and inhibit DNA and RNA synthesis and cell proliferation.
Psoriasis clinical practice guideline 2021, strong recommended Methotrexate therapy for the treatment of moderate to severe psoriasis.(class A)