Valproic acid exhibits its pharmacologic effects in a couple of ways, such as by acting on GABA (γ aminobutyric acid) levels in the CNS, blocking voltage-gated ion channels, and inhibiting histone deacetylase
It can be taken by adults (aged 18 and above) to help prevent migraine.
Dosage:
adults and older children (aged 12 years and over) – 600mg to 2,000mg a day, as 1 dose or split into 2 doses. Some people take a higher dose of 2,500mg a day
younger children (aged 1 month to 11 years) – the doctor will use your child's weight to work out the right dose for them
Mechanism of action:
Valproic acid exhibits its pharmacologic effects in a couple of ways, such as by acting on GABA (γ aminobutyric acid) levels in the CNS, blocking voltage-gated ion channels, and inhibiting histone deacetylase